Terperan
Brand names,
Terperan
Analogs
Terperan
Brand Names Mixture
Terperan
Chemical_Formula
C14H22ClN3O2
Terperan
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Terperan
fda sheet
Terperan
msds (material safety sheet)
Terperan
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Terperan
Molecular Weight
299.796 g/mol
Terperan
Melting Point
147.25 oC
Terperan
H2O Solubility
200 mg/L
Terperan
State
Solid
Terperan
LogP
2.464
Terperan
Dosage Forms
Liquid; Syrup; Tablet
Terperan
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Terperan
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Terperan
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Terperan
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Terperan
Patient Information
Terperan
Organisms Affected
Humans and other mammals