Primperan
Brand names,
Primperan
Analogs
Primperan
Brand Names Mixture
Primperan
Chemical_Formula
C14H22ClN3O2
Primperan
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Primperan
fda sheet
Primperan
msds (material safety sheet)
Primperan
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Primperan
Molecular Weight
299.796 g/mol
Primperan
Melting Point
147.25 oC
Primperan
H2O Solubility
200 mg/L
Primperan
State
Solid
Primperan
LogP
2.464
Primperan
Dosage Forms
Liquid; Syrup; Tablet
Primperan
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Primperan
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Primperan
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Primperan
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Primperan
Patient Information
Primperan
Organisms Affected
Humans and other mammals