Duraclamid
Brand names,
Duraclamid
Analogs
Duraclamid
Brand Names Mixture
Duraclamid
Chemical_Formula
C14H22ClN3O2
Duraclamid
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Duraclamid
fda sheet
Duraclamid
msds (material safety sheet)
Duraclamid
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Duraclamid
Molecular Weight
299.796 g/mol
Duraclamid
Melting Point
147.25 oC
Duraclamid
H2O Solubility
200 mg/L
Duraclamid
State
Solid
Duraclamid
LogP
2.464
Duraclamid
Dosage Forms
Liquid; Syrup; Tablet
Duraclamid
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Duraclamid
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Duraclamid
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Duraclamid
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Duraclamid
Patient Information
Duraclamid
Organisms Affected
Humans and other mammals