Metochlopramide
Brand names,
Metochlopramide
Analogs
Metochlopramide
Brand Names Mixture
Metochlopramide
Chemical_Formula
C14H22ClN3O2
Metochlopramide
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Metochlopramide
fda sheet
Metochlopramide
msds (material safety sheet)
Metochlopramide
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Metochlopramide
Molecular Weight
299.796 g/mol
Metochlopramide
Melting Point
147.25 oC
Metochlopramide
H2O Solubility
200 mg/L
Metochlopramide
State
Solid
Metochlopramide
LogP
2.464
Metochlopramide
Dosage Forms
Liquid; Syrup; Tablet
Metochlopramide
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Metochlopramide
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Metochlopramide
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Metochlopramide
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Metochlopramide
Patient Information
Metochlopramide
Organisms Affected
Humans and other mammals