Metoclol
Brand names,
Metoclol
Analogs
Metoclol
Brand Names Mixture
Metoclol
Chemical_Formula
C14H22ClN3O2
Metoclol
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Metoclol
fda sheet
Metoclol
msds (material safety sheet)
Metoclol
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Metoclol
Molecular Weight
299.796 g/mol
Metoclol
Melting Point
147.25 oC
Metoclol
H2O Solubility
200 mg/L
Metoclol
State
Solid
Metoclol
LogP
2.464
Metoclol
Dosage Forms
Liquid; Syrup; Tablet
Metoclol
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Metoclol
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Metoclol
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Metoclol
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Metoclol
Patient Information
Metoclol
Organisms Affected
Humans and other mammals