Metoclopramide Hydrochloride
Brand names,
Metoclopramide Hydrochloride
Analogs
Metoclopramide Hydrochloride
Brand Names Mixture
Metoclopramide Hydrochloride
Chemical_Formula
C14H22ClN3O2
Metoclopramide Hydrochloride
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Metoclopramide Hydrochloride
fda sheet
Metoclopramide Hydrochloride
msds (material safety sheet)
Metoclopramide Hydrochloride
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Metoclopramide Hydrochloride
Molecular Weight
299.796 g/mol
Metoclopramide Hydrochloride
Melting Point
147.25 oC
Metoclopramide Hydrochloride
H2O Solubility
200 mg/L
Metoclopramide Hydrochloride
State
Solid
Metoclopramide Hydrochloride
LogP
2.464
Metoclopramide Hydrochloride
Dosage Forms
Liquid; Syrup; Tablet
Metoclopramide Hydrochloride
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Metoclopramide Hydrochloride
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Metoclopramide Hydrochloride
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Metoclopramide Hydrochloride
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Metoclopramide Hydrochloride
Patient Information
Metoclopramide Hydrochloride
Organisms Affected
Humans and other mammals