Clopra
Brand names,
Clopra
Analogs
Clopra
Brand Names Mixture
Clopra
Chemical_Formula
C14H22ClN3O2
Clopra
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Clopra
fda sheet
Clopra
msds (material safety sheet)
Clopra
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Clopra
Molecular Weight
299.796 g/mol
Clopra
Melting Point
147.25 oC
Clopra
H2O Solubility
200 mg/L
Clopra
State
Solid
Clopra
LogP
2.464
Clopra
Dosage Forms
Liquid; Syrup; Tablet
Clopra
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Clopra
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Clopra
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Clopra
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Clopra
Patient Information
Clopra
Organisms Affected
Humans and other mammals