Meclopran
Brand names,
Meclopran
Analogs
Meclopran
Brand Names Mixture
Meclopran
Chemical_Formula
C14H22ClN3O2
Meclopran
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Meclopran
fda sheet
Meclopran
msds (material safety sheet)
Meclopran
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Meclopran
Molecular Weight
299.796 g/mol
Meclopran
Melting Point
147.25 oC
Meclopran
H2O Solubility
200 mg/L
Meclopran
State
Solid
Meclopran
LogP
2.464
Meclopran
Dosage Forms
Liquid; Syrup; Tablet
Meclopran
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Meclopran
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Meclopran
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Meclopran
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Meclopran
Patient Information
Meclopran
Organisms Affected
Humans and other mammals