Nu-Metoclopramide
Brand names,
Nu-Metoclopramide
Analogs
Nu-Metoclopramide
Brand Names Mixture
Nu-Metoclopramide
Chemical_Formula
C14H22ClN3O2
Nu-Metoclopramide
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Nu-Metoclopramide
fda sheet
Nu-Metoclopramide
msds (material safety sheet)
Nu-Metoclopramide
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Nu-Metoclopramide
Molecular Weight
299.796 g/mol
Nu-Metoclopramide
Melting Point
147.25 oC
Nu-Metoclopramide
H2O Solubility
200 mg/L
Nu-Metoclopramide
State
Solid
Nu-Metoclopramide
LogP
2.464
Nu-Metoclopramide
Dosage Forms
Liquid; Syrup; Tablet
Nu-Metoclopramide
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Nu-Metoclopramide
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Nu-Metoclopramide
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Nu-Metoclopramide
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Nu-Metoclopramide
Patient Information
Nu-Metoclopramide
Organisms Affected
Humans and other mammals