Gastrotablinen
Brand names,
Gastrotablinen
Analogs
Gastrotablinen
Brand Names Mixture
Gastrotablinen
Chemical_Formula
C14H22ClN3O2
Gastrotablinen
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Gastrotablinen
fda sheet
Gastrotablinen
msds (material safety sheet)
Gastrotablinen
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Gastrotablinen
Molecular Weight
299.796 g/mol
Gastrotablinen
Melting Point
147.25 oC
Gastrotablinen
H2O Solubility
200 mg/L
Gastrotablinen
State
Solid
Gastrotablinen
LogP
2.464
Gastrotablinen
Dosage Forms
Liquid; Syrup; Tablet
Gastrotablinen
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Gastrotablinen
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Gastrotablinen
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Gastrotablinen
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Gastrotablinen
Patient Information
Gastrotablinen
Organisms Affected
Humans and other mammals