Metocobil
Brand names,
Metocobil
Analogs
Metocobil
Brand Names Mixture
Metocobil
Chemical_Formula
C14H22ClN3O2
Metocobil
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Metocobil
fda sheet
Metocobil
msds (material safety sheet)
Metocobil
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Metocobil
Molecular Weight
299.796 g/mol
Metocobil
Melting Point
147.25 oC
Metocobil
H2O Solubility
200 mg/L
Metocobil
State
Solid
Metocobil
LogP
2.464
Metocobil
Dosage Forms
Liquid; Syrup; Tablet
Metocobil
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Metocobil
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Metocobil
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Metocobil
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Metocobil
Patient Information
Metocobil
Organisms Affected
Humans and other mammals