Metramid
Brand names,
Metramid
Analogs
Metramid
Brand Names Mixture
Metramid
Chemical_Formula
C14H22ClN3O2
Metramid
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Metramid
fda sheet
Metramid
msds (material safety sheet)
Metramid
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Metramid
Molecular Weight
299.796 g/mol
Metramid
Melting Point
147.25 oC
Metramid
H2O Solubility
200 mg/L
Metramid
State
Solid
Metramid
LogP
2.464
Metramid
Dosage Forms
Liquid; Syrup; Tablet
Metramid
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Metramid
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Metramid
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Metramid
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Metramid
Patient Information
Metramid
Organisms Affected
Humans and other mammals