Reliveran
Brand names,
Reliveran
Analogs
Reliveran
Brand Names Mixture
Reliveran
Chemical_Formula
C14H22ClN3O2
Reliveran
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Reliveran
fda sheet
Reliveran
msds (material safety sheet)
Reliveran
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Reliveran
Molecular Weight
299.796 g/mol
Reliveran
Melting Point
147.25 oC
Reliveran
H2O Solubility
200 mg/L
Reliveran
State
Solid
Reliveran
LogP
2.464
Reliveran
Dosage Forms
Liquid; Syrup; Tablet
Reliveran
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Reliveran
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Reliveran
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Reliveran
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Reliveran
Patient Information
Reliveran
Organisms Affected
Humans and other mammals