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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C14H22ClN3O2
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RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
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Molecular Weight
299.796 g/mol
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Melting Point
147.25 oC
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H2O Solubility
200 mg/L
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State
Solid
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LogP
2.464
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Dosage Forms
Liquid; Syrup; Tablet
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Indication
For the treatment of gastroesophageal reflux disease (GERD)
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Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
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Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
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side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
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Patient Information
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Organisms Affected
Humans and other mammals