Mygdalon
Brand names,
Mygdalon
Analogs
Mygdalon
Brand Names Mixture
Mygdalon
Chemical_Formula
C14H22ClN3O2
Mygdalon
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Mygdalon
fda sheet
Mygdalon
msds (material safety sheet)
Mygdalon
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Mygdalon
Molecular Weight
299.796 g/mol
Mygdalon
Melting Point
147.25 oC
Mygdalon
H2O Solubility
200 mg/L
Mygdalon
State
Solid
Mygdalon
LogP
2.464
Mygdalon
Dosage Forms
Liquid; Syrup; Tablet
Mygdalon
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Mygdalon
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Mygdalon
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Mygdalon
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Mygdalon
Patient Information
Mygdalon
Organisms Affected
Humans and other mammals