Apo-Metoclop
Brand names,
Apo-Metoclop
Analogs
Apo-Metoclop
Brand Names Mixture
Apo-Metoclop
Chemical_Formula
C14H22ClN3O2
Apo-Metoclop
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Apo-Metoclop
fda sheet
Apo-Metoclop
msds (material safety sheet)
Apo-Metoclop
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Apo-Metoclop
Molecular Weight
299.796 g/mol
Apo-Metoclop
Melting Point
147.25 oC
Apo-Metoclop
H2O Solubility
200 mg/L
Apo-Metoclop
State
Solid
Apo-Metoclop
LogP
2.464
Apo-Metoclop
Dosage Forms
Liquid; Syrup; Tablet
Apo-Metoclop
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Apo-Metoclop
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Apo-Metoclop
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Apo-Metoclop
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Apo-Metoclop
Patient Information
Apo-Metoclop
Organisms Affected
Humans and other mammals