Gastromax
Brand names,
Gastromax
Analogs
Gastromax
Brand Names Mixture
Gastromax
Chemical_Formula
C14H22ClN3O2
Gastromax
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Gastromax
fda sheet
Gastromax
msds (material safety sheet)
Gastromax
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Gastromax
Molecular Weight
299.796 g/mol
Gastromax
Melting Point
147.25 oC
Gastromax
H2O Solubility
200 mg/L
Gastromax
State
Solid
Gastromax
LogP
2.464
Gastromax
Dosage Forms
Liquid; Syrup; Tablet
Gastromax
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Gastromax
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Gastromax
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Gastromax
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Gastromax
Patient Information
Gastromax
Organisms Affected
Humans and other mammals