Octamide
Brand names,
Octamide
Analogs
Octamide
Brand Names Mixture
Octamide
Chemical_Formula
C14H22ClN3O2
Octamide
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Octamide
fda sheet
Octamide
msds (material safety sheet)
Octamide
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Octamide
Molecular Weight
299.796 g/mol
Octamide
Melting Point
147.25 oC
Octamide
H2O Solubility
200 mg/L
Octamide
State
Solid
Octamide
LogP
2.464
Octamide
Dosage Forms
Liquid; Syrup; Tablet
Octamide
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Octamide
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Octamide
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Octamide
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Octamide
Patient Information
Octamide
Organisms Affected
Humans and other mammals