Metamide
Brand names,
Metamide
Analogs
Metamide
Brand Names Mixture
Metamide
Chemical_Formula
C14H22ClN3O2
Metamide
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Metamide
fda sheet
Metamide
msds (material safety sheet)
Metamide
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Metamide
Molecular Weight
299.796 g/mol
Metamide
Melting Point
147.25 oC
Metamide
H2O Solubility
200 mg/L
Metamide
State
Solid
Metamide
LogP
2.464
Metamide
Dosage Forms
Liquid; Syrup; Tablet
Metamide
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Metamide
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Metamide
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Metamide
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Metamide
Patient Information
Metamide
Organisms Affected
Humans and other mammals