Metaclopromide
Brand names,
Metaclopromide
Analogs
Metaclopromide
Brand Names Mixture
Metaclopromide
Chemical_Formula
C14H22ClN3O2
Metaclopromide
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Metaclopromide
fda sheet
Metaclopromide
msds (material safety sheet)
Metaclopromide
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Metaclopromide
Molecular Weight
299.796 g/mol
Metaclopromide
Melting Point
147.25 oC
Metaclopromide
H2O Solubility
200 mg/L
Metaclopromide
State
Solid
Metaclopromide
LogP
2.464
Metaclopromide
Dosage Forms
Liquid; Syrup; Tablet
Metaclopromide
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Metaclopromide
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Metaclopromide
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Metaclopromide
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Metaclopromide
Patient Information
Metaclopromide
Organisms Affected
Humans and other mammals