Clopromate
Brand names,
Clopromate
Analogs
Clopromate
Brand Names Mixture
Clopromate
Chemical_Formula
C14H22ClN3O2
Clopromate
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Clopromate
fda sheet
Clopromate
msds (material safety sheet)
Clopromate
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Clopromate
Molecular Weight
299.796 g/mol
Clopromate
Melting Point
147.25 oC
Clopromate
H2O Solubility
200 mg/L
Clopromate
State
Solid
Clopromate
LogP
2.464
Clopromate
Dosage Forms
Liquid; Syrup; Tablet
Clopromate
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Clopromate
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Clopromate
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Clopromate
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Clopromate
Patient Information
Clopromate
Organisms Affected
Humans and other mammals