Metoclopramide Intensol
Brand names,
Metoclopramide Intensol
Analogs
Metoclopramide Intensol
Brand Names Mixture
Metoclopramide Intensol
Chemical_Formula
C14H22ClN3O2
Metoclopramide Intensol
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Metoclopramide Intensol
fda sheet
Metoclopramide Intensol
msds (material safety sheet)
Metoclopramide Intensol
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Metoclopramide Intensol
Molecular Weight
299.796 g/mol
Metoclopramide Intensol
Melting Point
147.25 oC
Metoclopramide Intensol
H2O Solubility
200 mg/L
Metoclopramide Intensol
State
Solid
Metoclopramide Intensol
LogP
2.464
Metoclopramide Intensol
Dosage Forms
Liquid; Syrup; Tablet
Metoclopramide Intensol
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Metoclopramide Intensol
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Metoclopramide Intensol
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Metoclopramide Intensol
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Metoclopramide Intensol
Patient Information
Metoclopramide Intensol
Organisms Affected
Humans and other mammals