Pramin
Brand names,
Pramin
Analogs
Pramin
Brand Names Mixture
Pramin
Chemical_Formula
C14H22ClN3O2
Pramin
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Pramin
fda sheet
Pramin
msds (material safety sheet)
Pramin
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Pramin
Molecular Weight
299.796 g/mol
Pramin
Melting Point
147.25 oC
Pramin
H2O Solubility
200 mg/L
Pramin
State
Solid
Pramin
LogP
2.464
Pramin
Dosage Forms
Liquid; Syrup; Tablet
Pramin
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Pramin
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Pramin
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Pramin
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Pramin
Patient Information
Pramin
Organisms Affected
Humans and other mammals