Gastrosil
Brand names,
Gastrosil
Analogs
Gastrosil
Brand Names Mixture
Gastrosil
Chemical_Formula
C14H22ClN3O2
Gastrosil
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Gastrosil
fda sheet
Gastrosil
msds (material safety sheet)
Gastrosil
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Gastrosil
Molecular Weight
299.796 g/mol
Gastrosil
Melting Point
147.25 oC
Gastrosil
H2O Solubility
200 mg/L
Gastrosil
State
Solid
Gastrosil
LogP
2.464
Gastrosil
Dosage Forms
Liquid; Syrup; Tablet
Gastrosil
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Gastrosil
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Gastrosil
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Gastrosil
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Gastrosil
Patient Information
Gastrosil
Organisms Affected
Humans and other mammals