Metoclopramide Omega
Brand names,
Metoclopramide Omega
Analogs
Metoclopramide Omega
Brand Names Mixture
Metoclopramide Omega
Chemical_Formula
C14H22ClN3O2
Metoclopramide Omega
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Metoclopramide Omega
fda sheet
Metoclopramide Omega
msds (material safety sheet)
Metoclopramide Omega
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Metoclopramide Omega
Molecular Weight
299.796 g/mol
Metoclopramide Omega
Melting Point
147.25 oC
Metoclopramide Omega
H2O Solubility
200 mg/L
Metoclopramide Omega
State
Solid
Metoclopramide Omega
LogP
2.464
Metoclopramide Omega
Dosage Forms
Liquid; Syrup; Tablet
Metoclopramide Omega
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Metoclopramide Omega
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Metoclopramide Omega
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Metoclopramide Omega
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Metoclopramide Omega
Patient Information
Metoclopramide Omega
Organisms Affected
Humans and other mammals