Peraprin
Brand names,
Peraprin
Analogs
Peraprin
Brand Names Mixture
Peraprin
Chemical_Formula
C14H22ClN3O2
Peraprin
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Peraprin
fda sheet
Peraprin
msds (material safety sheet)
Peraprin
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Peraprin
Molecular Weight
299.796 g/mol
Peraprin
Melting Point
147.25 oC
Peraprin
H2O Solubility
200 mg/L
Peraprin
State
Solid
Peraprin
LogP
2.464
Peraprin
Dosage Forms
Liquid; Syrup; Tablet
Peraprin
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Peraprin
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Peraprin
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Peraprin
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Peraprin
Patient Information
Peraprin
Organisms Affected
Humans and other mammals