Metaclopramide
Brand names,
Metaclopramide
Analogs
Metaclopramide
Brand Names Mixture
Metaclopramide
Chemical_Formula
C14H22ClN3O2
Metaclopramide
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Metaclopramide
fda sheet
Metaclopramide
msds (material safety sheet)
Metaclopramide
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Metaclopramide
Molecular Weight
299.796 g/mol
Metaclopramide
Melting Point
147.25 oC
Metaclopramide
H2O Solubility
200 mg/L
Metaclopramide
State
Solid
Metaclopramide
LogP
2.464
Metaclopramide
Dosage Forms
Liquid; Syrup; Tablet
Metaclopramide
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Metaclopramide
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Metaclopramide
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Metaclopramide
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Metaclopramide
Patient Information
Metaclopramide
Organisms Affected
Humans and other mammals