Reglan
Brand names,
Reglan
Analogs
Reglan
Brand Names Mixture
Reglan
Chemical_Formula
C14H22ClN3O2
Reglan
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Reglan
fda sheet
Reglan
msds (material safety sheet)
Reglan
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Reglan
Molecular Weight
299.796 g/mol
Reglan
Melting Point
147.25 oC
Reglan
H2O Solubility
200 mg/L
Reglan
State
Solid
Reglan
LogP
2.464
Reglan
Dosage Forms
Liquid; Syrup; Tablet
Reglan
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Reglan
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Reglan
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Reglan
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Reglan
Patient Information
Reglan
Organisms Affected
Humans and other mammals