Gastrese
Brand names,
Gastrese
Analogs
Gastrese
Brand Names Mixture
Gastrese
Chemical_Formula
C14H22ClN3O2
Gastrese
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
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fda sheet
Gastrese
msds (material safety sheet)
Gastrese
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Gastrese
Molecular Weight
299.796 g/mol
Gastrese
Melting Point
147.25 oC
Gastrese
H2O Solubility
200 mg/L
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State
Solid
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LogP
2.464
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Dosage Forms
Liquid; Syrup; Tablet
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Indication
For the treatment of gastroesophageal reflux disease (GERD)
Gastrese
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Gastrese
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Gastrese
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
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Patient Information
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Organisms Affected
Humans and other mammals