Parmid
Brand names,
Parmid
Analogs
Parmid
Brand Names Mixture
Parmid
Chemical_Formula
C14H22ClN3O2
Parmid
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Parmid
fda sheet
Parmid
msds (material safety sheet)
Parmid
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Parmid
Molecular Weight
299.796 g/mol
Parmid
Melting Point
147.25 oC
Parmid
H2O Solubility
200 mg/L
Parmid
State
Solid
Parmid
LogP
2.464
Parmid
Dosage Forms
Liquid; Syrup; Tablet
Parmid
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Parmid
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Parmid
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Parmid
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Parmid
Patient Information
Parmid
Organisms Affected
Humans and other mammals