Paspertin
Brand names,
Paspertin
Analogs
Paspertin
Brand Names Mixture
Paspertin
Chemical_Formula
C14H22ClN3O2
Paspertin
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Paspertin
fda sheet
Paspertin
msds (material safety sheet)
Paspertin
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Paspertin
Molecular Weight
299.796 g/mol
Paspertin
Melting Point
147.25 oC
Paspertin
H2O Solubility
200 mg/L
Paspertin
State
Solid
Paspertin
LogP
2.464
Paspertin
Dosage Forms
Liquid; Syrup; Tablet
Paspertin
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Paspertin
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Paspertin
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Paspertin
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Paspertin
Patient Information
Paspertin
Organisms Affected
Humans and other mammals