Cerucal
Brand names,
Cerucal
Analogs
Cerucal
Brand Names Mixture
Cerucal
Chemical_Formula
C14H22ClN3O2
Cerucal
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Cerucal
fda sheet
Cerucal
msds (material safety sheet)
Cerucal
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Cerucal
Molecular Weight
299.796 g/mol
Cerucal
Melting Point
147.25 oC
Cerucal
H2O Solubility
200 mg/L
Cerucal
State
Solid
Cerucal
LogP
2.464
Cerucal
Dosage Forms
Liquid; Syrup; Tablet
Cerucal
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Cerucal
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Cerucal
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Cerucal
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Cerucal
Patient Information
Cerucal
Organisms Affected
Humans and other mammals