Metoclopramide Hcl
Brand names,
Metoclopramide Hcl
Analogs
Metoclopramide Hcl
Brand Names Mixture
Metoclopramide Hcl
Chemical_Formula
C14H22ClN3O2
Metoclopramide Hcl
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Metoclopramide Hcl
fda sheet
Metoclopramide Hcl
msds (material safety sheet)
Metoclopramide Hcl
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Metoclopramide Hcl
Molecular Weight
299.796 g/mol
Metoclopramide Hcl
Melting Point
147.25 oC
Metoclopramide Hcl
H2O Solubility
200 mg/L
Metoclopramide Hcl
State
Solid
Metoclopramide Hcl
LogP
2.464
Metoclopramide Hcl
Dosage Forms
Liquid; Syrup; Tablet
Metoclopramide Hcl
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Metoclopramide Hcl
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Metoclopramide Hcl
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Metoclopramide Hcl
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Metoclopramide Hcl
Patient Information
Metoclopramide Hcl
Organisms Affected
Humans and other mammals