Clopra-Yellow
Brand names,
Clopra-Yellow
Analogs
Clopra-Yellow
Brand Names Mixture
Clopra-Yellow
Chemical_Formula
C14H22ClN3O2
Clopra-Yellow
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Clopra-Yellow
fda sheet
Clopra-Yellow
msds (material safety sheet)
Clopra-Yellow
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Clopra-Yellow
Molecular Weight
299.796 g/mol
Clopra-Yellow
Melting Point
147.25 oC
Clopra-Yellow
H2O Solubility
200 mg/L
Clopra-Yellow
State
Solid
Clopra-Yellow
LogP
2.464
Clopra-Yellow
Dosage Forms
Liquid; Syrup; Tablet
Clopra-Yellow
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Clopra-Yellow
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Clopra-Yellow
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Clopra-Yellow
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Clopra-Yellow
Patient Information
Clopra-Yellow
Organisms Affected
Humans and other mammals