Plasil
Brand names,
Plasil
Analogs
Plasil
Brand Names Mixture
Plasil
Chemical_Formula
C14H22ClN3O2
Plasil
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Plasil
fda sheet
Plasil
msds (material safety sheet)
Plasil
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Plasil
Molecular Weight
299.796 g/mol
Plasil
Melting Point
147.25 oC
Plasil
H2O Solubility
200 mg/L
Plasil
State
Solid
Plasil
LogP
2.464
Plasil
Dosage Forms
Liquid; Syrup; Tablet
Plasil
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Plasil
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Plasil
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Plasil
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Plasil
Patient Information
Plasil
Organisms Affected
Humans and other mammals