Gastrotem
Brand names,
Gastrotem
Analogs
Gastrotem
Brand Names Mixture
Gastrotem
Chemical_Formula
C14H22ClN3O2
Gastrotem
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Gastrotem
fda sheet
Gastrotem
msds (material safety sheet)
Gastrotem
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Gastrotem
Molecular Weight
299.796 g/mol
Gastrotem
Melting Point
147.25 oC
Gastrotem
H2O Solubility
200 mg/L
Gastrotem
State
Solid
Gastrotem
LogP
2.464
Gastrotem
Dosage Forms
Liquid; Syrup; Tablet
Gastrotem
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Gastrotem
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Gastrotem
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Gastrotem
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Gastrotem
Patient Information
Gastrotem
Organisms Affected
Humans and other mammals