Wigraine
Brand names,
Wigraine
Analogs
Wigraine
Brand Names Mixture
Wigraine
Chemical_Formula
C8H10N4O2
Wigraine
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
Wigraine
fda sheet
Wigraine
msds (material safety sheet)
Wigraine
Synthesis Reference
U.S. Pat. 2,508,545 (1950)
Wigraine
Molecular Weight
194.191 g/mol
Wigraine
Melting Point
238 oC
Wigraine
H2O Solubility
22 mg/ml
Wigraine
State
Solid
Wigraine
LogP
-0.07
Wigraine
Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
Wigraine
Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Wigraine
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
Wigraine
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
Wigraine
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
Wigraine
Patient Information
Wigraine
Organisms Affected
Humans and other mammals