Coffein
Brand names,
Coffein
Analogs
Coffein
Brand Names Mixture
Coffein
Chemical_Formula
C8H10N4O2
Coffein
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
Coffein
fda sheet
Coffein
msds (material safety sheet)
Coffein
Synthesis Reference
U.S. Pat. 2,508,545 (1950)
Coffein
Molecular Weight
194.191 g/mol
Coffein
Melting Point
238 oC
Coffein
H2O Solubility
22 mg/ml
Coffein
State
Solid
Coffein
LogP
-0.07
Coffein
Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
Coffein
Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Coffein
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
Coffein
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
Coffein
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
Coffein
Patient Information
Coffein
Organisms Affected
Humans and other mammals