Cafergot
Brand names,
Cafergot
Analogs
Cafergot
Brand Names Mixture
Cafergot
Chemical_Formula
C8H10N4O2
Cafergot
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
Cafergot
fda sheet
Cafergot
msds (material safety sheet)
Cafergot
Synthesis Reference
U.S. Pat. 2,508,545 (1950)
Cafergot
Molecular Weight
194.191 g/mol
Cafergot
Melting Point
238 oC
Cafergot
H2O Solubility
22 mg/ml
Cafergot
State
Solid
Cafergot
LogP
-0.07
Cafergot
Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
Cafergot
Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Cafergot
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
Cafergot
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
Cafergot
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
Cafergot
Patient Information
Cafergot
Organisms Affected
Humans and other mammals