Guaranine
Brand names,
Guaranine
Analogs
Guaranine
Brand Names Mixture
Guaranine
Chemical_Formula
C8H10N4O2
Guaranine
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
Guaranine
fda sheet
Guaranine
msds (material safety sheet)
Guaranine
Synthesis Reference
U.S. Pat. 2,508,545 (1950)
Guaranine
Molecular Weight
194.191 g/mol
Guaranine
Melting Point
238 oC
Guaranine
H2O Solubility
22 mg/ml
Guaranine
State
Solid
Guaranine
LogP
-0.07
Guaranine
Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
Guaranine
Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Guaranine
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
Guaranine
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
Guaranine
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
Guaranine
Patient Information
Guaranine
Organisms Affected
Humans and other mammals