Caffeine, Synthetic
Brand names,
Caffeine, Synthetic
Analogs
Caffeine, Synthetic
Brand Names Mixture
Caffeine, Synthetic
Chemical_Formula
C8H10N4O2
Caffeine, Synthetic
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
Caffeine, Synthetic
fda sheet
Caffeine, Synthetic
msds (material safety sheet)
Caffeine, Synthetic
Synthesis Reference
U.S. Pat. 2,508,545 (1950)
Caffeine, Synthetic
Molecular Weight
194.191 g/mol
Caffeine, Synthetic
Melting Point
238 oC
Caffeine, Synthetic
H2O Solubility
22 mg/ml
Caffeine, Synthetic
State
Solid
Caffeine, Synthetic
LogP
-0.07
Caffeine, Synthetic
Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
Caffeine, Synthetic
Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Caffeine, Synthetic
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
Caffeine, Synthetic
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
Caffeine, Synthetic
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
Caffeine, Synthetic
Patient Information
Caffeine, Synthetic
Organisms Affected
Humans and other mammals