Caffeine, Monohydrate
Brand names,
Caffeine, Monohydrate
Analogs
Caffeine, Monohydrate
Brand Names Mixture
Caffeine, Monohydrate
Chemical_Formula
C8H10N4O2
Caffeine, Monohydrate
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
Caffeine, Monohydrate
fda sheet
Caffeine, Monohydrate
msds (material safety sheet)
Caffeine, Monohydrate
Synthesis Reference
U.S. Pat. 2,508,545 (1950)
Caffeine, Monohydrate
Molecular Weight
194.191 g/mol
Caffeine, Monohydrate
Melting Point
238 oC
Caffeine, Monohydrate
H2O Solubility
22 mg/ml
Caffeine, Monohydrate
State
Solid
Caffeine, Monohydrate
LogP
-0.07
Caffeine, Monohydrate
Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
Caffeine, Monohydrate
Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Caffeine, Monohydrate
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
Caffeine, Monohydrate
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
Caffeine, Monohydrate
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
Caffeine, Monohydrate
Patient Information
Caffeine, Monohydrate
Organisms Affected
Humans and other mammals