Compound 65
Brand names,
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Analogs
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Brand Names Mixture
Compound 65
Chemical_Formula
C8H10N4O2
Compound 65
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
Compound 65
fda sheet
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msds (material safety sheet)
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Synthesis Reference
U.S. Pat. 2,508,545 (1950)
Compound 65
Molecular Weight
194.191 g/mol
Compound 65
Melting Point
238 oC
Compound 65
H2O Solubility
22 mg/ml
Compound 65
State
Solid
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LogP
-0.07
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Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
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Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Compound 65
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
Compound 65
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
Compound 65
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
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Patient Information
Compound 65
Organisms Affected
Humans and other mammals