Coffeine
Brand names,
Coffeine
Analogs
Coffeine
Brand Names Mixture
Coffeine
Chemical_Formula
C8H10N4O2
Coffeine
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
Coffeine
fda sheet
Coffeine
msds (material safety sheet)
Coffeine
Synthesis Reference
U.S. Pat. 2,508,545 (1950)
Coffeine
Molecular Weight
194.191 g/mol
Coffeine
Melting Point
238 oC
Coffeine
H2O Solubility
22 mg/ml
Coffeine
State
Solid
Coffeine
LogP
-0.07
Coffeine
Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
Coffeine
Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Coffeine
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
Coffeine
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
Coffeine
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
Coffeine
Patient Information
Coffeine
Organisms Affected
Humans and other mammals