No-Doz
Brand names,
No-Doz
Analogs
No-Doz
Brand Names Mixture
No-Doz
Chemical_Formula
C8H10N4O2
No-Doz
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
No-Doz
fda sheet
No-Doz
msds (material safety sheet)
No-Doz
Synthesis Reference
U.S. Pat. 2,508,545 (1950)
No-Doz
Molecular Weight
194.191 g/mol
No-Doz
Melting Point
238 oC
No-Doz
H2O Solubility
22 mg/ml
No-Doz
State
Solid
No-Doz
LogP
-0.07
No-Doz
Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
No-Doz
Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
No-Doz
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
No-Doz
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
No-Doz
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
No-Doz
Patient Information
No-Doz
Organisms Affected
Humans and other mammals