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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C8H10N4O2
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RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
U.S. Pat. 2,508,545 (1950)
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Molecular Weight
194.191 g/mol
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Melting Point
238 oC
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H2O Solubility
22 mg/ml
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State
Solid
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LogP
-0.07
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Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
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Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
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Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
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Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
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side effects and Toxicity
LD50=127 mg/kg (orally in mice)
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Patient Information
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Organisms Affected
Humans and other mammals