Diurex
Brand names,
Diurex
Analogs
Diurex
Brand Names Mixture
Diurex
Chemical_Formula
C8H10N4O2
Diurex
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
Diurex
fda sheet
Diurex
msds (material safety sheet)
Diurex
Synthesis Reference
U.S. Pat. 2,508,545 (1950)
Diurex
Molecular Weight
194.191 g/mol
Diurex
Melting Point
238 oC
Diurex
H2O Solubility
22 mg/ml
Diurex
State
Solid
Diurex
LogP
-0.07
Diurex
Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
Diurex
Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Diurex
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
Diurex
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
Diurex
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
Diurex
Patient Information
Diurex
Organisms Affected
Humans and other mammals