Monomethyl Derivative of Theophylline
Brand names,
Monomethyl Derivative of Theophylline
Analogs
Monomethyl Derivative of Theophylline
Brand Names Mixture
Monomethyl Derivative of Theophylline
Chemical_Formula
C8H10N4O2
Monomethyl Derivative of Theophylline
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
Monomethyl Derivative of Theophylline
fda sheet
Monomethyl Derivative of Theophylline
msds (material safety sheet)
Monomethyl Derivative of Theophylline
Synthesis Reference
U.S. Pat. 2,508,545 (1950)
Monomethyl Derivative of Theophylline
Molecular Weight
194.191 g/mol
Monomethyl Derivative of Theophylline
Melting Point
238 oC
Monomethyl Derivative of Theophylline
H2O Solubility
22 mg/ml
Monomethyl Derivative of Theophylline
State
Solid
Monomethyl Derivative of Theophylline
LogP
-0.07
Monomethyl Derivative of Theophylline
Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
Monomethyl Derivative of Theophylline
Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Monomethyl Derivative of Theophylline
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
Monomethyl Derivative of Theophylline
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
Monomethyl Derivative of Theophylline
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
Monomethyl Derivative of Theophylline
Patient Information
Monomethyl Derivative of Theophylline
Organisms Affected
Humans and other mammals