Orphengesic Forte
Brand names,
Orphengesic Forte
Analogs
Orphengesic Forte
Brand Names Mixture
Orphengesic Forte
Chemical_Formula
C8H10N4O2
Orphengesic Forte
RX_link
http://www.rxlist.com/cgi/generic3/caffeine.htm
Orphengesic Forte
fda sheet
Orphengesic Forte
msds (material safety sheet)
Orphengesic Forte
Synthesis Reference
U.S. Pat. 2,508,545 (1950)
Orphengesic Forte
Molecular Weight
194.191 g/mol
Orphengesic Forte
Melting Point
238 oC
Orphengesic Forte
H2O Solubility
22 mg/ml
Orphengesic Forte
State
Solid
Orphengesic Forte
LogP
-0.07
Orphengesic Forte
Dosage Forms
Capsule; Drops; Liquid; Pill; Tablet
Orphengesic Forte
Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Orphengesic Forte
Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.
Orphengesic Forte
Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.
Orphengesic Forte
side effects and Toxicity
LD50=127 mg/kg (orally in mice)
Orphengesic Forte
Patient Information
Orphengesic Forte
Organisms Affected
Humans and other mammals