Medroxyprogesterone
Brand names,
Medroxyprogesterone
Analogs
Medroxyprogesterone
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Medroxyprogesterone
Chemical_Formula
C22H32O3
Medroxyprogesterone
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Medroxyprogesterone
fda sheet
Medroxyprogesterone
msds (material safety sheet)
Medroxyprogesterone
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Medroxyprogesterone
Molecular Weight
344.488 g/mol
Medroxyprogesterone
Melting Point
220 - 223.5 oC
Medroxyprogesterone
H2O Solubility
22.2mg/L
Medroxyprogesterone
State
Solid
Medroxyprogesterone
LogP
3.606
Medroxyprogesterone
Dosage Forms
Tablets; Depo injection
Medroxyprogesterone
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Medroxyprogesterone
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Medroxyprogesterone
Absorption
Rapidly absorbed from GI tract
Medroxyprogesterone
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Medroxyprogesterone
Patient Information
Medroxyprogesterone
Organisms Affected
Humans and other mammals